Cancer Institute A national cancer institute
designated cancer center

Philip W. Lavori

Publication Details

  • Implementation of an iron reduction protocol in patients with peripheral vascular disease: VA Cooperative Study No. 410: The iron (Fe) and atherosclerosis study (FeAST) AMERICAN HEART JOURNAL Zacharski, L. R., Chow, B. K., Howes, P. S., Lavori, P. W., Shamayeva, G. 2004; 148 (3): 386-392


    Iron accumulates imperceptibly over time in adults because intake exceeds loss and because no physiologic mechanism exists for excreting levels that may be toxic. Levels of stored iron represented by the serum ferritin concentration have been implicated in the pathogenesis of vascular (and other) diseases, but the role of such stored iron remains controversial. Our hypothesis was that reduction in body iron stores to levels typical of children and premenopausal women (corresponding to ferritin levels of approximately 25 ng/mL) would alter morbidity and mortality rates in patients with advanced peripheral vascular disease.A randomized, single-blinded, clinical trial of graded reduction of iron stores by controlled phlebotomy was undertaken in patients with advanced peripheral vascular disease. Details of implementation of the protocol for testing this unusual experimental intervention are reported.A methodology is described for testing the concept that reduction of body iron stores (while avoiding iron deficiency) may alter disease outcomes. This methodology appears to be suitable for further testing to determine whether levels of iron stores presumed to be pathologic contribute to disease initiation or progression.

    View details for DOI 10.1016/j.ahj.2004.03.027

    View details for Web of Science ID 000224339600003

    View details for PubMedID 15389223

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