Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Extracellular replication of Listeria monocytogenes in the murine gall bladder SCIENCE Hardy, J., Francis, K. P., deBoer, M., Chu, P., Gibbs, K., Contag, C. H. 2004; 303 (5659): 851-853


    The bacterium Listeria monocytogenes can cause a life-threatening systemic illness in humans. Despite decades of progress in animal models of listeriosis, much remains unknown about the processes of infection and colonization. Here, we report that L. monocytogenes can replicate in the murine gall bladder and provide evidence that its replication there is extracellular and intraluminal. In vivo bioluminescence imaging was employed to determine the location of the infection over time in live animals, revealing strong signals from the gall bladder over a period of several days, in diseased as well as asymptomatic animals. The data suggest that L. monocytogenes may be carried in the human gall bladder.

    View details for Web of Science ID 000188753800062

    View details for PubMedID 14764883

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