Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Enzyme activity - it's all about image TRENDS IN CELL BIOLOGY Baruch, A., Jeffery, D. A., Bogyo, M. 2004; 14 (1): 29-35


    Unraveling the functional roles of proteins is a major challenge facing the postgenome researcher. Advances towards this goal have been made through the development of both chemical and biochemical tools for monitoring protein activity. Recently, a myriad of fluorescence-based imaging tools have emerged for in vitro, in vivo and whole animal applications. These tools have provided methods to monitor the spatial and temporal distribution of proteins and bioorganic molecules dynamically. Here, recent advances in chemical and biochemical techniques that allow the detection of enzymatic activity within intact cells and in vivo are reviewed. Such technologies have the potential to be integrated into drug-development programs to facilitate both the functional validation of pharmaceutical targets and the treatment of human disease.

    View details for DOI 10.1016/j.tcb.2003.11.002

    View details for Web of Science ID 000188599000006

    View details for PubMedID 14729178

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