Cancer Institute A national cancer institute
designated cancer center

Stefanie S. Jeffrey, MD

Publication Details

  • The diagnosis and management of pre-invasive breast disease - Promise of new technologies in understanding pre-invasive breast lesions BREAST CANCER RESEARCH Jeffrey, S. S., Pollack, J. R. 2003; 5 (6): 320-328


    Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated because they provided ample quantities of DNA, RNA, and protein. The application of these technologies to pre-invasive breast lesions is discussed, including methods that facilitate their implementation. Data indicate that atypical ductal hyperplasia and ductal carcinoma in situ are precursor lesions molecularly similar to adjacent invasive breast cancer. It is expected that molecular technologies will identify breast tissue at risk for the development of unfavorable subtypes of invasive breast cancer and reveal strategies for targeted chemoprevention or eradication.

    View details for DOI 10.1186/bcr655

    View details for Web of Science ID 000185946100009

    View details for PubMedID 14580250

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