Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • THE WNT GENE FAMILY IN TUMORIGENESIS AND IN NORMAL DEVELOPMENT Nusse, R. PERGAMON-ELSEVIER SCIENCE LTD. 1992: 9-12

    Abstract:

    Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis.

    View details for Web of Science ID A1992JM32400003

    View details for PubMedID 1388050

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