Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Nwabugwu, C. I., Rakhra, K., Felsher, D. W., Paik, D. S. 2013; 2013: 4529-4532


    Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.

    View details for DOI 10.1109/EMBC.2013.6610554

    View details for PubMedID 24110741

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