Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Development of activity-based probes for trypsin-family serine proteases BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Pan, Z. Y., Jeffery, D. A., Chehade, K., Beltman, J., Clark, J. M., Grothaus, P., Bogyo, M., Baruch, A. 2006; 16 (11): 2882-2885

    Abstract:

    A series of diphenylphosphonate-based probes were developed for the trypsin-like serine proteases. These probes selectively target serine proteases rather than general serine hydrolases that are targets for fluorophosphonate-based probes. This increased selectivity allows detection of low abundance serine proteases in complex proteomes using simple SDS-PAGE methods. We present here the application of multiple probes in enzyme activity profiling of intact mast cells, a type of inflammatory cell implicated in allergy and autoimmune diseases.

    View details for DOI 10.1016/j.bmcl.2006.03.012

    View details for Web of Science ID 000237407800011

    View details for PubMedID 16554154

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