Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages FEBS LETTERS Konjar, S., Yin, F., Bogyo, M., Turk, B., Kopitar-Jerala, N. 2010; 584 (11): 2201-2206


    Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus and co-localization with cathepsin L, upon classical, but not alternative activation of macrophages. Despite the increased expression of cathepsin L in the nuclei of classically activated macrophages, no cathepsin activity was detected. Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens.

    View details for DOI 10.1016/j.febslet.2010.03.031

    View details for Web of Science ID 000277793200005

    View details for PubMedID 20338168

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