Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Verdoes, M., Bender, K. O., Segal, E., van der Linden, W. A., Syed, S., Withana, N. P., Sanman, L. E., Bogyo, M. 2013; 135 (39): 14726-14730

    Abstract:

    The cysteine cathepsins are a family of proteases that play important roles in both normal cellular physiology and many human diseases. In cancer, the activity of many of the cysteine cathepsins is upregulated and can be exploited for tumor imaging. Here we present the design and synthesis of a new class of quenched fluorescent activity-based probes (qABPs) containing a phenoxymethyl ketone (PMK) electrophile. These reagents show enhanced in vivo properties and broad reactivity resulting in dramatically improved labeling and tumor imaging properties compared to those of previously reported ABPs.

    View details for DOI 10.1021/ja4056068

    View details for Web of Science ID 000326300500042

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