Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Dual-axis confocal microscope for high-resolution in vivo imaging OPTICS LETTERS Wang, T. D., Mandella, M. J., Contag, C. H., Kino, G. S. 2003; 28 (6): 414-416


    We describe a novel confocal microscope that uses separate low-numerical-aperture objectives with the illumination and collection axes crossed at angle theta from the midline. This architecture collects images in scattering media with high transverse and axial resolution, long working distance, large field of view, and reduced noise from scattered light. We measured transverse and axial (FWHM) resolution of 1.3 and 2.1 microm, respectively, in free space, and confirm subcellular resolution in excised esophageal mucosa. The optics may be scaled to millimeter dimensions and fiber coupled for collection of high-resolution images in vivo.

    View details for Web of Science ID 000181411300012

    View details for PubMedID 12659264

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