Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • DISHEVELLED AND ARMADILLO ACT IN THE WINGLESS SIGNALING PATHWAY IN DROSOPHILA NATURE Noordermeer, J., Klingensmith, J., Perrimon, N., Nusse, R. 1994; 367 (6458): 80-83


    The Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.

    View details for Web of Science ID A1994MP86500064

    View details for PubMedID 7906389

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