Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling CELL Tree, D. R., Shulman, J. M., Rousset, R., Scott, M. P., Gubb, D., Axelrod, J. D. 2002; 109 (3): 371-381


    Planar cell polarity signaling in Drosophila requires the receptor Frizzled and the cytoplasmic proteins Dishevelled and Prickle. From initial, symmetric subcellular distributions in pupal wing cells, Frizzled and Dishevelled become highly enriched at the distal portion of the cell cortex. We describe a Prickle-dependent intercellular feedback loop that generates asymmetric Frizzled and Dishevelled localization. In the absence of Prickle, Frizzled and Dishevelled remain symmetrically distributed. Prickle localizes to the proximal side of pupal wing cells and binds the Dishevelled DEP domain, inhibiting Dishevelled membrane localization and antagonizing Frizzled accumulation. This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces.

    View details for Web of Science ID 000175412100012

    View details for PubMedID 12015986

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