Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Wingless repression of Drosophila frizzled 2 expression shapes the wingless morphogen gradient in the wing CELL Cadigan, K. M., Fish, M. P., Rulifson, E. J., Nusse, R. 1998; 93 (5): 767-777


    In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range. Here, we show that high levels of a Wg receptor, Drosophila frizzled 2 (Dfz2), stabilize Wg, allowing it to reach cells far from its site of synthesis. Wg signaling represses Dfz2 expression, creating a gradient of decreasing Wg stability moving toward the D/V boundary. This repression of Dfz2 is crucial for the normal shape of Wg morphogen gradient as well as the response of cells to the Wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation.

    View details for Web of Science ID 000073956700013

    View details for PubMedID 9630221

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