Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • beta-catenin: a key mediator of Wnt signaling CURRENT OPINION IN GENETICS & DEVELOPMENT Willert, K., Nusse, R. 1998; 8 (1): 95-102


    Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.

    View details for Web of Science ID 000072681300014

    View details for PubMedID 9529612

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