James D. Brooks
Publication Details
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Gene expression changes induced by unilateral ureteral obstruction in mice.
J Urol. 2012; (3): 1033-41
Loss of renal function is often the impetus for operative intervention in renal obstruction cases. Obstructive nephropathy is characterized by discrete morphological and physiological changes, including tubular dilatation, apoptosis and atrophy as well as interstitial cellular infiltration and progressive interstitial fibrosis. We hypothesized that gene expression alterations correlate with obstructive nephropathy and could serve as biomarkers for early intervention.
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