Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gamma delta T cell, G8 JOURNAL OF EXPERIMENTAL MEDICINE Crowley, M. P., Reich, Z., Mavaddat, N., Altman, J. D., Chien, Y. H. 1997; 185 (7): 1223-1230


    Recent studies have shown that many nonclassical major histocompatibility complex (MHC) (class 1b) molecules have distinct antigen-binding capabilities, including the binding of nonpeptide moieties and the binding of peptides that are different from those bound to classical MHC molecules. Here, we show that one of the H-2T region-encoded molecules, T10, when produced in Escherichia coli, can be folded in vitro with beta2-microglobulin (beta2m) to form a stable heterodimer in the absence of peptide or nonpeptide moieties. This heterodimer can be recognized by specific antibodies and is stimulatory to the gammadelta T cell clone, G8. Circular dichroism analysis indicates that T10/beta2m has structural features distinct from those of classical MHC class I molecules. These results suggest a new way for MHC-like molecules to adopt a peptide-free structure and to function in the immune system.

    View details for Web of Science ID A1997WU18300008

    View details for PubMedID 9104809

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