Cancer Institute A national cancer institute
designated cancer center

Nelson Teng

Publication Details

  • V(H)4-34(V(H)4.21) gene expression in the chronic arthritides of childhood: Studies of associations with anti-lipid a antibodies, HLA antigens, and clinical features JOURNAL OF RHEUMATOLOGY Miller, J. J., Bieber, M. M., Levinson, J. E., Zhu, S. L., Tsou, E., Teng, N. N. 1996; 23 (12): 2132-2139

    Abstract:

    To determine if the germ line gene VH4-34 (VH4.21) encodes the antimonophosphoryl lipid A (MPL) polyspecific antibodies found in oligoarticular arthritis of childhood.Sera from a range of rheumatic diseases of childhood were assayed for VH4-34 derived antibodies by ELISA using the antiidiotype monoclonal antibody 9G4. Results were compared to assays for anti-MPL antibodies, C4d, and Bb, and for HLA type, joint count, and sedimentation rate.VH4-34 derived antibodies were elevated in all diseases studied except rheumatoid factor positive polyarticular disease. In oligoarticular arthritis, VH4-34 gene expression correlated with C4d concentration, and VH4-34 encoded globulins were more concentrated in synovial fluid than in blood. No association was found with HLA type. An association between VH4-34 expression and IgG anti-MPL was found in sera from patients from Cincinnati but not from Stanford. No other evidence supported a direct association between VH4-34 derived and anti-MPL antibodies in these children.The expression of VH4-34 is increased in several rheumatic diseases of childhood, but, as in adults, not in rheumatoid arthritis. VH4-34 expression is not associated with HLA type. The polyspecific autoantibody nature of some VH4-34 derived antibodies may explain the wide range of the unusual antibodies found in oligoarticular arthritis.

    View details for Web of Science ID A1996VX84300022

    View details for PubMedID 8970052

Stanford Medicine Resources:

Footer Links: