Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction NATURE Wiertz, E. J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., JONES, T. R., Rapoport, T. A., Ploegh, H. L. 1996; 384 (6608): 432-438


    The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

    View details for Web of Science ID A1996VW68700053

    View details for PubMedID 8945469

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