Jean Y. Tang MD PhD
Publication Details
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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.
N Engl J Med. 2012; (23): 2180-8
Dysregulated hedgehog signaling is the pivotal molecular abnormality underlying basal-cell carcinomas. Vismodegib is a new orally administered hedgehog-pathway inhibitor that produces objective responses in locally advanced and metastatic basal-cell carcinomas.
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