Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Interaction between wingless and notch signaling pathways mediated by dishevelled SCIENCE Axelrod, J. D., Matsuno, K., ARTAVANISTSAKONAS, S., Perrimon, N. 1996; 271 (5257): 1826-1832


    In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

    View details for Web of Science ID A1996UC77800035

    View details for PubMedID 8596950

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