Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • HOW ALPHA-BETA-T-CELL RECEPTORS SEE PEPTIDE MHC COMPLEXES IMMUNOLOGY TODAY Chien, Y. H., DAVIS, M. M. 1993; 14 (12): 597-602

    Abstract:

    Recent results have added new information to our understanding of alpha beta T-cell receptor mediated recognition. In particular, we find that the V(D)J junction or 'CDR3' portion of TCR alpha and beta seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions. Surprisingly, these same CDR3-peptide contacts also appear to have a major influence on the TCR-MHC molecule interactions as well.

    View details for Web of Science ID A1993MK79800005

    View details for PubMedID 8305132

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