Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • CDR3 LENGTH IN ANTIGEN-SPECIFIC IMMUNE RECEPTORS JOURNAL OF EXPERIMENTAL MEDICINE ROCK, E. P., SIBBALD, P. R., DAVIS, M. M., Chien, Y. H. 1994; 179 (1): 323-328

    Abstract:

    In both immunoglobulins (Ig) and T cell receptors (TCR), the rearrangement of V, D, and J region sequence elements during lymphocyte maturation creates an enormous degree of diversity in an area referred to as the complementarity determining region 3 (CDR3) loop. Variations in the particular V, D, and J elements used, precise points of recombination, and random nucleotide addition all lead to extensive length and sequence heterogeneity. CDR3 loops are often critical for antigen binding in Igs and appear to provide the principal peptide binding residues in TCRs. To better understand the physical and selective constraints on these sequences, we have compiled information on CDR3 size variation for Ig H, L (kappa and lambda) and TCR alpha, beta, gamma, and delta. Ig H and TCR delta CDR3s are the most variable in size and are significantly longer than L and gamma chains, respectively. In contrast, TCR alpha and beta chain distributions are highly constrained, with nearly identical average CDR3 lengths, and their length distributions are not altered by thymic selection. Perhaps most significantly, these CDR3 length profiles suggest that gamma/delta TCRs are more similar to Igs than to alpha/beta TCRs in their putative ligand binding region, and thus gamma/delta and alpha/beta T cells may have fundamentally different recognition properties.

    View details for Web of Science ID A1994MP51700033

    View details for PubMedID 8270877

Stanford Medicine Resources:

Footer Links: