Cancer Institute A national cancer institute
designated cancer center

RobertĀ W. Carlson

Publication Details

  • IMPACT OF OMEPRAZOLE ON THE PLASMA-CLEARANCE OF METHOTREXATE CANCER CHEMOTHERAPY AND PHARMACOLOGY Reid, T., Yuen, A., CATOLICO, M., Carlson, R. W. 1993; 33 (1): 82-84

    Abstract:

    Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.

    View details for Web of Science ID A1993MC70700014

    View details for PubMedID 8269594

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