Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION TO 17Q21 OF THE HUMAN WNT3-GENE GENOMICS Roelink, H., Wang, J., Black, D. M., Solomon, E., Nusse, R. 1993; 17 (3): 790-792


    In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. Here we report on the isolation of a human homolog, WNT3. A genomic clone was isolated by use of mouse Wnt-3 sequences as a probe, after which cDNA containing most of the protein-encoding domain of the human gene was obtained by PCR. Comparison between the deduced mouse and human WNT-3 protein sequences showed four changes in 333 amino acids. WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors.

    View details for Web of Science ID A1993LX23300045

    View details for PubMedID 8244403

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