Cancer Institute A national cancer institute
designated cancer center

Philip W. Lavori

Publication Details

  • BIPOLAR-I - A 5-YEAR PROSPECTIVE FOLLOW-UP JOURNAL OF NERVOUS AND MENTAL DISEASE Keller, M. B., Lavori, P. W., Coryell, W., Endicott, J., Mueller, T. I. 1993; 181 (4): 238-245


    We explored the course of bipolar I illness in 172 probands who were followed up prospectively for up to 5 years. Probands were grouped into three categories based on whether the symptoms of the index episode were only depressed, only manic, or mixed/cycling. Data were available for recovery from the index episode, subsequent relapse, and rates of recovery from the first prospective episode. Pure manic probands had a significantly faster rate of recovery (median, 6 weeks) than the mixed/cycling probands (median, 17 weeks), and the pure depressive probands had an intermediate rate (median, 11 weeks). After 5 years of follow-up the mixed/cycling patients continue to have the lowest cumulative probability of recovery from the index episode. Mixed/cycling probands also had a substantially faster time to relapse after recovery from the index episode compared with pure manic patients. For those patients who relapsed, the mixed/cycling patients had the lowest cumulative probability of recovery from the first prospectively observed episode. The treatment received by these patients is described and there is a discussion of how this treatment may have influenced the findings on course and outcome.

    View details for Web of Science ID A1993KX48800005

    View details for PubMedID 8097229

Stanford Medicine Resources:

Footer Links: