Cancer Institute A national cancer institute
designated cancer center

Michael Link

Publication Details

  • SECONDARY BREAST-CANCER IN PATIENTS PRESENTING WITH OSTEOSARCOMA - POSSIBLE INVOLVEMENT OF GERMLINE P53 MUTATIONS MEDICAL AND PEDIATRIC ONCOLOGY Russo, C. L., McIntyre, J., Goorin, A. M., Link, M. P., Gebhardt, M. C., Friend, S. H. 1994; 23 (4): 354-358

    Abstract:

    Second malignancies following treatment for osteosarcoma are unusual. Breast cancer occurring in patients with osteosarcoma has been reported following therapeutic chest irradiation. We now report three cases of breast cancer occurring in young women who were successfully treated for osteosarcoma. These women had not received therapeutic chest irradiation and in two of the three women there was no family history of breast cancer. Peripheral blood was available for study from one case. Of import, this case demonstrated a germline mutation in exon 7 of the tumor suppressor gene, p53. The mutation was detected by constant denaturing gradient gel electrophoresis and confirmed by DNA sequencing. In this particular patient, inactivation of the p53 gene may be involved in the development of both the first and second malignancy.

    View details for Web of Science ID A1994PD28400006

    View details for PubMedID 8058007

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