Publication Details

Cytotoxic T lymphocyte responses against melanocytes and melanoma.

Chang GY, Kohrt HE, Stuge TB, Schwartz EJ, Weber JS, Lee PP. J Transl Med. 2011; 9 (1): 122

Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs) against melanoma commonly target melanoma-associated antigens (MAAs) which are also expressed by melanocytes. To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels.

PubMedID: 21794122