Cancer Institute A national cancer institute
designated cancer center

Frederick M. Dirbas

Publication Details

  • EXPERIMENTS ON THE ABIOTIC AMPLIFICATION OF OPTICAL-ACTIVITY ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES Bonner, W. A., Blair, N. E., Dirbas, F. M. 1981; 11 (1-2): 119-134

    Abstract:

    Our earlier experiments are briefly reviewed, involving the abiotic generation of optical activity by exposure of DL-amino acids to various "chiral" physical forces. The enantiomeric enrichments so obtained were low, however, and additional experiments were undertaken with the objective of abiotically enhancing such small enantiomeric excesses. D not equal to L Mixtures of leucine N-carboxy anhydride gave enantiomerically enriched polymers on partial polymerization, while valine NCA mixtures behaved oppositely. Leucine polymers were also found to hydrolyze stereoselectively, providing for additional enantiomeric enhancement. A repetitive sequence of partial polymerization-hydrolysis steps is suggested as a possible mechanism for the abiotic genesis of optically enriched polypeptides on the primitive Earth.

    View details for Web of Science ID A1981LJ65100011

    View details for PubMedID 7231975

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