Branimir I. Sikic, M. D.
Publication Details
-
Clinical trial designs for testing biomarker-based personalized therapies.
Clin Trials. 2012; (2): 141-54
Advances in molecular therapeutics in the past decade have opened up new possibilities for treating cancer patients with personalized therapies, using biomarkers to determine which treatments are most likely to benefit them, but there are difficulties and unresolved issues in the development and validation of biomarker-based personalized therapies. We develop a new clinical trial design to address some of these issues. The goal is to capture the strengths of the frequentist and Bayesian approaches to address this problem in the recent literature and to circumvent their limitations.
Help
Trial Administration