Cancer Institute A national cancer institute
designated cancer center

Philip W. Lavori

Publication Details

  • PREDICTORS OF RELAPSE IN MAJOR DEPRESSIVE DISORDER JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Keller, M. B., Lavori, P. W., Lewis, C. E., Klerman, G. L. 1983; 250 (24): 3299-3304

    Abstract:

    Risk of relapse into an affective episode was high in the months immediately after recovery from a major depressive disorder (MDD) in 141 subjects with nonbipolar depression, without a preexisting dysthymic disorder. The probability of relapse then declined steadily during the duration of the follow-up (median follow-up, 62 weeks from recovery). In patients entering the study during their first affective episode, the Research Diagnostic Criteria secondary subtype of MDD and an older age of onset predicted a significantly greater likelihood of relapse. Three or more prior episodes of depression predicted a significantly shorter time to the first and second prospectively observed relapses and, thus, a significantly greater likelihood of subsequent multiple affective episodes.

    View details for Web of Science ID A1983RW60800020

    View details for PubMedID 6645026

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