Cancer Institute A national cancer institute
designated cancer center

Philip W. Lavori

Publication Details

  • AGE PERIOD COHORT ANALYSIS OF SECULAR TRENDS IN ONSET OF MAJOR DEPRESSION - FINDINGS IN SIBLINGS OF PATIENTS WITH MAJOR AFFECTIVE-DISORDER JOURNAL OF PSYCHIATRIC RESEARCH Lavori, P. W., Klerman, G. L., Keller, M. B., Reich, T., Rice, J., Endicott, J. 1987; 21 (1): 23-35

    Abstract:

    Analyses of data from the NIMH-CRB Collaborative Depression Study on age at onset of Major Depressive Disorder (MDD) in 1144 directly interviewed siblings of patients with major affective disorder show a strong secular trend toward increased lifetime risk and earlier onset in successive cohorts of birth since 1930. The proportionate increases in the instantaneous probabilities (hazard) of onset of MDD for each one year difference in year of birth were 5% for brothers and 7% for sisters. Age-period-cohort analysis suggests a powerful period effect may be responsible for this secular trend in rates of MDD, with rates of onset for siblings between 15 and 50 years of age doubling between the 1960s and 1970s. Possible artifacts are investigated.

    View details for Web of Science ID A1987G560500003

    View details for PubMedID 3560005

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