Cancer Institute A national cancer institute
designated cancer center

Frank E. Stockdale

Publication Details

  • COMBINED MODALITY THERAPY OF LOCALLY ADVANCED BREAST-CANCER - ONE INSTITUTIONS EXPERIENCE AND A REVIEW OF THE LITERATURE ANTICANCER RESEARCH Hu, E., Stockdale, F. E., Turner, B., Carlson, R. W., Levine, J., KUSHLAN, P. 1987; 7 (4): 733-736

    Abstract:

    Fourteen patients with locally advanced breast cancer were treated at Stanford University Medical Center with a combined modality approach. Treatment consisted of an initial 5 day course of cyclophosphamide followed by three cycles of combination chemotherapy (CAF or CMF). Patients subsequently received radiation therapy to the involved breast and regional nodal areas, followed by mastectomy if resistant disease was present following irradiation. Additional chemotherapy (CMF) was administered for 6 cycles. With a median follow up of 42 months, all fourteen patients are free of local disease. Five out of the fourteen patients have experienced distant relapses and two patients died. We conclude that an aggressive combined modality approach to treatment of locally advanced breast cancer can result in excellent local control and survival even in poor prognosis patients. A review of pertinent studies on multimodality treatment for locally advanced breast cancer confirms our findings.

    View details for Web of Science ID A1987K599800011

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