Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • VARIABLE REGION (V-SIGMA) GENE SEGMENT MOST FREQUENTLY UTILIZED IN ADULT THYMOCYTES IS 3' OF THE CONSTANT (C-SIGMA) REGION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Iwashima, M., Green, A., DAVIS, M. M., Chien, Y. H. 1988; 85 (21): 8161-8165

    Abstract:

    A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

    View details for Web of Science ID A1988Q834100070

    View details for PubMedID 3263646

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