Cancer Institute A national cancer institute
designated cancer center

Nelson Teng

Publication Details

  • TOPICAL INTERFERON FOR TREATING CONDYLOMA ACUMINATA IN WOMEN JOURNAL OF INFECTIOUS DISEASES Keay, S., Teng, N., Eisenberg, M., Story, B., SELLERS, P. W., Merigan, T. C. 1988; 158 (5): 934-939

    Abstract:

    We conducted a randomized, double-blind, placebo-controlled trial of two forms of topical interferon therapy for condyloma acuminata in women. Gel containing 10(6) IU of leukocyte interferon/g, with or without nonoxynol-9, was compared with treatment with gel base alone. Eighty-nine patients applied the gel three times a day for four weeks and were studied for at least 16 w. Side effects were generally mild and limited to the site of application for all three drugs. Although a transient, statistically significant therapeutic effect was noted early in the course of treatment with both interferon gels as compared with placebo, this effect was lost by the end of the follow-up period, possibly because of a generally high response rate in patients receiving placebo. Hence, there was no overall difference in the number of patients with a partial or complete response to any of the agents by the end of therapy or by the end of the study.

    View details for Web of Science ID A1988Q700100004

    View details for PubMedID 2460568

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