Cancer Institute A national cancer institute
designated cancer center

Julien Sage

Publication Details

  • Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression JOURNAL OF EXPERIMENTAL MEDICINE Garfin, P. M., Min, D., Bryson, J. L., Serwold, T., Edris, B., Blackburn, C. C., Richie, E. R., Weinberg, K. I., Manley, N. R., Sage, J., Viatour, P. 2013; 210 (6): 1087-1097


    Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged thymus competent for increased production of naive T cells. This phenotype originates from the expansion of functional thymic epithelial cells (TECs). In RB family mutant TECs, increased activity of E2F transcription factors drives increased expression of Foxn1, a central regulator of the thymic epithelium. Increased Foxn1 expression is required for the thymic expansion observed in Rb family mutant mice. Thus, the RB family promotes thymic involution and controls T cell production via a bone marrow-independent mechanism, identifying a novel pathway to target to increase thymic function in patients.

    View details for DOI 10.1084/jem.20121716

    View details for Web of Science ID 000319807800004

    View details for PubMedID 23669396

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