Cancer Institute A national cancer institute
designated cancer center

Julien Sage

Publication Details

  • RB goes mitochondrial GENES & DEVELOPMENT Attardi, L. D., Sage, J. 2013; 27 (9): 975-979


    The retinoblastoma tumor suppressor RB is well known for its capacity to restrict cell cycle progression at the G1/S transition of the cell cycle by controlling the transcription of cell cycle genes. In this issue of Genes & Development, Hilgendorf and colleagues (pp. 1003-1015) have identified a novel tumor suppressor function for RB independent of its role as a transcriptional regulator, in which RB directly activates the apoptosis regulator Bax at the mitochondria to promote cell death.

    View details for DOI 10.1101/gad.219451.113

    View details for Web of Science ID 000318700800002

    View details for PubMedID 23651852

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