Cancer Institute A national cancer institute
designated cancer center

Anthony Oro MD/PhD

Publication Details

  • "Patch"ing up our tumor signaling knowledge. journal of investigative dermatology Atwood, S. X., Whitson, R. J., Oro, A. E. 2013; 133 (5): 1131-1133


    The tumor suppressor Patched1 (Ptch1) possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventing the formation of basal cell carcinomas (BCCs). In this issue, Kang et al. extend their previous work to show that a naturally occurring allele of Ptch1 found in FVB mice promotes early squamous cell carcinoma (SCC) growth without aberrant activation of the SHH pathway. The study reveals new roles for Ptch1 that lie at the nexus between BCC and SCC formation.

    View details for DOI 10.1038/jid.2012.506

    View details for PubMedID 23594533

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