Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • Characterization of MYC-Induced Tumorigenesis by in Situ Lipid Profiling ANALYTICAL CHEMISTRY Perry, R. H., Bellovin, D. I., Shroff, E. H., Ismail, A. I., Zabuawala, T., Felsher, D. W., Zare, R. N. 2013; 85 (9): 4259-4262


    We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and off has led to the discovery of highly specific lipid molecules associated with MYC-induced tumor onset. We are able to distinguish normal from MYC-induced malignant cells. Our approach provides a strategy to define a precise molecular picture at a resolution of about 200 ?m that may be useful in identifying lipid molecules that define how the MYC oncogene initiates and maintains tumorigenesis.

    View details for DOI 10.1021/ac400479j

    View details for Web of Science ID 000318756100008

    View details for PubMedID 23560736

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