Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • A Mathematical Model to Study the Dynamics of Epithelial Cellular Networks IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS Abate, A., Vincent, S., Dobbe, R., Silletti, A., Master, N., Axelrod, J. D., Tomlin, C. J. 2012; 9 (6): 1607-1620

    Abstract:

    Epithelia are sheets of connected cells that are essential across the animal kingdom. Experimental observations suggest that the dynamical behavior of many single-layered epithelial tissues has strong analogies with that of specific mechanical systems, namely large networks consisting of point masses connected through spring-damper elements and undergoing the influence of active and dissipating forces. Based on this analogy, this work develops a modeling framework to enable the study of the mechanical properties and of the dynamic behavior of large epithelial cellular networks. The model is built first by creating a network topology that is extracted from the actual cellular geometry as obtained from experiments, then by associating a mechanical structure and dynamics to the network via spring-damper elements. This scalable approach enables running simulations of large network dynamics: the derived modeling framework in particular is predisposed to be tailored to study general dynamics (for example, morphogenesis) of various classes of single-layered epithelial cellular networks. In this contribution, we test the model on a case study of the dorsal epithelium of the Drosophila melanogaster embryo during early dorsal closure (and, less conspicuously, germband retraction).

    View details for DOI 10.1109/TCBB.2012.126

    View details for Web of Science ID 000312558400006

    View details for PubMedID 23221083

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