Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Remodeling a Tissue: Subtraction Adds Insight SCIENCE SIGNALING Axelrod, J. D. 2012; 5 (252)


    Sculpting a body plan requires both patterning of gene expression and translating that pattern into morphogenesis. Developmental biologists have made remarkable strides in understanding gene expression patterning, but despite a long history of fascination with the mechanics of morphogenesis, knowledge of how patterned gene expression drives the emergence of even simple shapes and forms has grown at a slower pace. The successful merging of approaches from cell biology, developmental biology, imaging, engineering, and mathematical and computational sciences is now accelerating progress toward a fuller and better integrated understanding of the forces shaping morphogenesis.

    View details for DOI 10.1126/scisignal.2003620

    View details for Web of Science ID 000311749700003

    View details for PubMedID 23193158

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