Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • gamma delta T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response IMMUNITY Zeng, X., Wei, Y., Huang, J., Newell, E. W., Yu, H., Kidd, B. A., Kuhns, M. S., Waters, R. W., Davis, M. M., Weaver, C. T., Chien, Y. 2012; 37 (3): 524-534


    ?? T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most ?? T cells recognize, what is required for them to mount an immune response, and how the ?? T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human ?? T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive ?? T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific ?? T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow ?? T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.

    View details for DOI 10.1016/j.immuni.2012.06.011

    View details for Web of Science ID 000309199000016

    View details for PubMedID 22960222

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