Cancer Institute A national cancer institute
designated cancer center

Quynh-Thu Le, MD

Publication Details

  • Volumetric-Modulated Arc Radiotherapy for Skull-Base and Non-Skull-Base Head and Neck Cancer: A Treatment Planning Comparison with Fixed Beam IMRT TECHNOLOGY IN CANCER RESEARCH & TREATMENT Chen, J., Mok, E., Wang, L., Chen, C., Quynh-Thu Le, Q. T. 2013; 12 (1): 11-18

    Abstract:

    The purpose of this study is to compare the dose distribution, monitor units (MUs) and radiation delivery time between volumetric-modulated arc (VMAT) and fix-beam intensity modulated radiotherapy (FB-IMRT) in skull-base and non-skull-base head and neck cancer (HNC). CT datasets of 8 skull-base and 7 non-skull-base HNC were identified. IMRT and VMAT plans were generated. The prescription dose ranged 45-70?Gy (1.8-2.2?Gy/fraction). The VMAT delivery time was measured when these plans were delivered to the patients. The FB-IMRT delivery time was generated on a phantom. Comparison of dose-volume histogram data, MUs, and delivery times was performed using T-test. Our results show that both plans yield similar target volume coverage, homogeneity, and conformity. In skull-base cases, compared to FB-IMRT, VMAT generated significantly smaller hot-spot inside PTV (2.0% vs. 4.5%, p =?0.031), lower maximum chiasm dose (32 ±?11?Gy vs. 41 ±?15?Gy, p =?0.026), lower ipsilateral temporal-mandibular joint dose (D33: 41.4?Gy vs. 46.1?Gy, p =?0.016), lower mean ipsilateral middle ear dose (43 ±?9?Gy vs. 38 ±?10?Gy, p =?0.020) and a trend for lower optic nerve, temporal lobe, parotid, and oral cavity dose. In non-skull-base cases, doses to normal tissues were similar between the two plans. There was a reduction of 70% in MUs (486 ±?95 vs. 1614 ±?493, p

    View details for DOI 10.7785/tcrt.2012.500251

    View details for Web of Science ID 000312607600002

    View details for PubMedID 22905805

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