Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Developmental Stage and Time Dictate the Fate of Wnt/beta-Catenin-Responsive Stem Cells in the Mammary Gland CELL STEM CELL van Amerongen, R., Bowman, A. N., Nusse, R. 2012; 11 (3): 387-400


    The mammary epithelium undergoes extensive growth and remodeling during pregnancy, suggesting a role for stem cells. Yet their origin, identity, and behavior in the intact tissue remain unknown. Using an Axin2(CreERT2) allele, we labeled and traced Wnt/?-catenin-responsive cells throughout mammary gland development. This reveals a switch in Wnt/?-catenin signaling around birth and shows that, depending on the developmental stage, Axin2(+) cells contribute differently to basal and luminal epithelial cell lineages of the mammary epithelium. Moreover, an important difference exists between the developmental potential tested in transplantation assays and that displayed by the same cell population in situ. Finally, Axin2(+) cells in the adult build alveolar structures during multiple pregnancies, demonstrating the existence of a Wnt/?-catenin-responsive adult stem cell. Our study uncovers dynamic changes in Wnt/?-catenin signaling in the mammary epithelium and offers insights into the developmental fate of mammary gland stem and progenitor cells.

    View details for DOI 10.1016/j.stem.2012.05.023

    View details for Web of Science ID 000309641300012

    View details for PubMedID 22863533

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