Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Three decades of Wnts: a personal perspective on how a scientific field developed EMBO JOURNAL Nusse, R., Varmus, H. 2012; 31 (12): 2670-2684


    Wnt genes and components of Wnt signalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviours to several diseases, especially cancers. Emergence of the field of Wnt signalling can be largely traced back to the discovery of the first mammalian Wnt gene in 1982. In this essay, we mark the thirtieth anniversary of that discovery by describing some of the critical scientific developments that led to the flowering of this field of research.

    View details for DOI 10.1038/emboj.2012.146

    View details for Web of Science ID 000305299200002

    View details for PubMedID 22617420

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