Cancer Institute A national cancer institute
designated cancer center

Manish J. Butte, MD PhD

Publication Details

  • Optical planar waveguide for cell counting. Applied physics letters Leblanc, J., Mueller, A. J., Prinz, A., Butte, M. J. 2012; 100 (4): 43701-437015


    Low cost counting of cells has medical applications in screening, military medicine, disaster medicine, and rural healthcare. In this report, we present a shallow, buried, planar waveguide fabricated by potassium ion exchange in glass that enables low-cost and rapid counting of metal-tagged objects that lie in the evanescent field of the waveguide. Laser light transmitted through the waveguide was attenuated proportionately to the presence of metal-coated microstructures fabricated from photoresist. This technology enables the low-cost enumeration of cells from blood, urine, or other biofluids.

    View details for PubMedID 22331960

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