Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Location, Location, Location: FoxM1 Mediates beta-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis CANCER CELL Bowman, A., Nusse, R. 2011; 20 (4): 415-416


    Genetic alterations in the Wnt/?-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates ?-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/?-catenin pathway activation.

    View details for DOI 10.1016/j.ccr.2011.10.003

    View details for Web of Science ID 000296121300001

    View details for PubMedID 22014565

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