Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Unipolar membrane association of dishevelled mediates frizzled planar cell polarity signaling GENES & DEVELOPMENT Axelrod, J. D. 2001; 15 (10): 1182-1187


    Drosophila epithelia acquire a planar cell polarity (PCP) orthogonal to their apical-basal axes. Frizzled (Fz) is the receptor for the PCP signal, and Dishevelled (Dsh) transduces the signal. Here, I demonstrate that unipolar relocalization of Dsh to the membrane is required to mediate PCP, but not Wingless (Wg) signaling. Dsh membrane localization reflects the activation of Fz/PCP signaling, revealing that the initially symmetric signal evolves to one that displays unipolar asymmetry, specifying the cells' ultimate polarity. This transition from symmetric to asymmetric Dsh localization requires Dsh function, and reflects an amplification process that generates a steep intracellular activity gradient necessary to determine PCP.

    View details for Web of Science ID 000168930600002

    View details for PubMedID 11358862

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