Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Proteases as regulators of pathogenesis: Examples from the Apicomplexa BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS Li, H., Child, M. A., Bogyo, M. 2012; 1824 (1): 177-185

    Abstract:

    The diverse functional roles that proteases play in basic biological processes make them essential for virtually all organisms. Not surprisingly, proteolysis is also a critical process required for many aspects of pathogenesis. In particular, obligate intracellular parasites must precisely coordinate proteolytic events during their highly regulated life cycle inside multiple host cell environments. Advances in chemical, proteomic and genetic tools that can be applied to parasite biology have led to an increased understanding of the complex events centrally regulated by proteases. In this review, we outline recent advances in our knowledge of specific proteolytic enzymes in two medically relevant apicomplexan parasites: Plasmodium falciparum and Toxoplasma gondii. Efforts over the last decade have begun to provide a map of key proteotolyic events that are essential for both parasite survival and propagation inside host cells. These advances in our molecular understanding of proteolytic events involved in parasite pathogenesis provide a foundation for the validation of new networks and enzyme targets that could be exploited for therapeutic purposes. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.

    View details for DOI 10.1016/j.bbapap.2011.06.002

    View details for Web of Science ID 000298715900018

    View details for PubMedID 21683169

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