Cancer Institute A national cancer institute
designated cancer center

Ian Carroll, MD, MS

Publication Details

  • HIV Tat represses transcription of the beta(2)-microglobulin promoter MOLECULAR IMMUNOLOGY Carroll, I. R., Wang, J., Howcroft, T. K., Singer, D. S. 1998; 35 (18): 1171-1178

    Abstract:

    The MHC class I complex, which binds and presents peptide antigen, is composed of a class I heavy chain and the beta2-microglobulin light chain. HIV-1, which induces a profound immunodeficiency in infected individuals, encodes proteins that cause decreased expression of class I heavy chain. We now report that the HIV Tat protein, which is a potent transactivator of viral transcription, is also a potent repressor of the beta2-microglobulin gene. Repression is mediated through the basal promoter of the beta2-microglobulin gene, which is shown to be predominantly regulated by an initiator element. Tat repression is further augmented by the short viral transcript, TAR, which interacts with Tat. Tat-mediated repression of beta2-microglobulin expression, together with its known repression of class I gene transcription, provides an effective mechanism by which HIV could prevent cell surface expression of the MHC class I complex and avoid immune surveillance.

    View details for Web of Science ID 000079458800003

    View details for PubMedID 10199391

Stanford Medicine Resources:

Footer Links: