Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Kapoor, R., Eimerman, P. R., Hardy, J. W., Cirillo, J. D., Contag, C. H., Barron, A. E. 2011; 55 (6): 3058-3062

    Abstract:

    Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids--previously reported as mimics of natural host defense peptides--for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C13(4mer)) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 1(4mer), was inactive. Peptoid 1-C13(4mer) thus merits further study as a potential antituberculosis drug.

    View details for DOI 10.1128/AAC.01667-10

    View details for Web of Science ID 000290713400091

    View details for PubMedID 21464254

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